KRAS的信号通路

KRAS信号的激活是一个多办法的历程，，，，，需要适当的KRAS翻译后修饰，，，，，细胞膜定位与效应卵白的相互作用。。。。。

The activation of KRAS signaling is a multi-step process that requires proper KRAS post-translation，，，，，plasma membrane-localization and interaction with effector proteins.

在细胞外刺激作用下，，，，，从失活的RAS-GDP到激活的RAS-GDP的转化进一步增进了多种信号通路的激活，，，，，包括MAPK通路、PI3k 通路和Ral-GEFs通路，，，，，其中以MAPK通路的特征最为显着。。。。。

In response to extracellular stimuli, the conversion from inactive RAS-GDP to active RAS-GDP further promotes the activation of various signaling pathways, which includes MAPK pathway，，，，，PI3k pathway and the Ral-GEFs pathway,among them the MAPK pathway is the best characterized.

RAS-GDP直接与RAF卵白连系，，，，，将RAF激酶家族从细胞质招募到膜上，，，，，在细胞膜上二聚化并活化。。。。。激活的RAF随后对其下游底物，，，，，即MEK and ERk举行一系列磷酸化反应，，，，，并传导生长信号。。。。。

RAS-GDP directly binds to RAF protein,recruiting RAF Kinese family from cytoplasm to membranes，，，，，where they dimerize and become active. The activated RAF subsequently carries out a chain of phospholation reactions to its downstream substrates, MEK and ERk, and propagates the growth signal.

KRAS新药研发平台

什么是KRAS?

yl23455永利助力信诺维抗肿瘤1类新药XNW14010（小分子KRAS G12C卵白共价连系抑制剂）获批临床