开发和验证大鼠血浆中Nobiliside A定量的LC/MS/MS要领

Nobiliside A, a new triterpene glycoside, exhibits some biological activities including antifungal and cytotoxic effects. A LC/MS/MS method was developed and validated for determination of Nobiliside A in rat plasma, would prove to be useful for other pharmacokinetic assessments. Male SD rats were housed in Medicilon animal facility. The animal experiments of the present study were approved by IACUC of Medicilon and were carried out in accordance with the SOPs of the facility.

Reference:

Dan Guo, et al. Development and validation of a LC/MS/MS method for quantification of nobiliside A in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 15;877(3):323-7. doi: 10.1016/j.jchromb.2008.12.007.